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					much enhanced penetration and permeation of pharmaceutically active substances through the skin barriercreation of a drug depot guaranteeing a long-term effect at the target site and thus reducing the frequency of dosing and the total treatment timeimproved benefit/risk ratio (reduction in side-effects by prevention of toxic plasma concentrations)higher product safety by more accurate dosage, due to the more exact spray systemrapid penetration of the whole formulation into the skin without leaving a residual fatty surface film (making surgical dressing unnecessary)no need for additional gelling substances, known to inhibit drug penetrationno need for additional preserving substances, causing further problems in patients with allergiesno gastro-intestinal or hepatic first-pass effectsminimal risk of gastro-intestinal side-effects |  |